Everything you need to know about Methylene Blue...

So, what exactly is Methylene Blue & what does it do?


TL;DR
Methylene blue is a man-made compound. It's been used in biology & medical research.

The unexpected discovery during it's use as a dye to view cells under a microscope was it's interaction & impact on the cell's energy production.

What it can mean for you when you take it - more energy, healthier cells, better mental health.


Methylene blue is a synthetic compound first developed in 1876 by German chemist Heinrich Caro. Originally used as a textile dye, it quickly gained attention for its medicinal properties. In the late 19th and early 20th centuries, it became one of the first synthetic drugs used to treat malaria. Scientists also discovered it worked well as a stain for viewing cells under a microscope, which made it really useful in early biology and medical research.

When methylene blue was first used to stain cells for microscopy, researchers quickly noticed that it wasn’t just a passive dye—it actually interacted with the cells themselves. Specifically, it binds to certain cellular structures like mitochondria and nucleic acids, which helped scientists visualise those parts more clearly. But over time, they also discovered that methylene blue could influence how cells function.

It turns out methylene blue can affect the cell’s energy production by interacting with the mitochondria - the powerhouses of the cell. It can help improve the efficiency of the electron transport chain, a crucial step in making cellular energy (ATP). This unexpected biological activity is what eventually led to its broader medical use and the growing interest in its health benefits today.

all day energy

without caffeine

improved mood

and reduced stress

no brain fog

and boosted memory

Methylene Blue FAQ

Is Methylene Blue safe to use?

Our methylene blue is lab-tested to USP-grade standards and verified to be free from heavy metals. We place a strong emphasis on purity and ensure only the highest-quality ingredients are used.

What’s the recommended starting dose?

Research suggests effective antioxidant benefits with doses between 5–15mg. Most users find 5mg (about 20 drops from our dropper) to be ideal. We advise beginning with a smaller amount, such as 5–10 drops, to gauge your personal response.

How should I take it?

While some people like to drop it directly into their tongues, we recommend mixing with water, juice or a flavored drink for taste and to avoid a stained mouth! It can be taken on an empty stomach, or with food.

What effects should I expect?

Many users experience a noticeable boost in energy, focus, and mood soon after taking it—often described as an improved sense of well-being. However, some people may require a few days or an increased dose before feeling the effects.

What are the key benefits of daily use?

Users often report sustained, stimulant-free energy, sharper concentration, better mood regulation, and short-term memory improvements. A mild bluish-green discoloration of urine is also common. Over time, research indicates Methylene Blue may also help with:

  • Brain health and memory
  • Inflammation
  • Viral and bacterial resistance
  • Skin health and signs of aging
I felt off after the first dose—is that normal?

It doesn't happen to everyone but it can and it's normal. Methylene blue is known for its antimicrobial action, which can cause a Herxheimer reaction as your body clears out pathogens. If you feel unwell, pause use for a few days, stay hydrated, and resume at a lower dose.

Why is my wee green or blue?

This is completely normal and expected. The colour of your urine can vary depending on your dose, hydration levels, and diet.

Does Methylene Blue interfere with fasting?

No—it actually complements fasting. It enhances mitochondrial function and promotes autophagy, supporting the benefits of intermittent or extended fasting.

How long does a bottle last?

This depends on your daily dose. A 30ml bottle will usually last at least 4 weeks. 

How quickly does it start working?

Most users report noticeable cognitive improvements within 30 minutes, including enhanced focus and mental clarity. Mood and energy boosts are often felt within two hours, with longer-term benefits developing over weeks.

When’s the best time to take it?

For most people, taking Methylene Blue in the morning is ideal due to its energy-boosting effects. However, it does not contain stimulants and may also be taken in the afternoon. Some prefer to split the dose between morning and early afternoon for prolonged focus.

How does it work in the body?

Methylene Blue supports energy production at the cellular level while acting as a powerful antioxidant. It enhances mitochondrial efficiency and reduces oxidative stress by aiding electron transfer in your cells' energy systems.

So in simple terms, Methylene Blue helps your cells make energy more efficiently, kind of like giving your body’s batteries a boost. It also works like a shield that protects your cells from damage caused by stress and pollution inside your body.

What’s the proper way to store it?

Store your bottle in a cool, dry, and dark place—ideally between 15–20°C. Refrigeration isn’t necessary. Even after opening, the product remains stable at room temperature. You can pre-mix single doses with juice and refrigerate them for convenience.

Can I take it with medication?

Speak with your healthcare provider before use. Methylene Blue can interact with certain medications—especially those affecting serotonin or dopamine (such as SSRIs, SNRIs, MAOIs, and some antidepressants). Avoid use if pregnant, breastfeeding, or experiencing kidney issues. Some sources suggest CoQ-10 may reduce its effectiveness.

Is it scientifically supported?

Yes. There is a growing body of peer-reviewed studies exploring Methylene Blue’s neuroprotective, antioxidant, and antimicrobial effects. Visit our Research page for curated research and expert insights.

Is it safe for children?

Always consult a medical professional before giving Methylene Blue to children.