Methylene Blue Improves Mitochondrial Function in Human Fibroblasts
https://www.fasebj.org/doi/10.1096/fj.07-8560com
This laboratory study investigated methylene blue's effects on mitochondrial function in human fibroblast cells. The researchers discovered that methylene blue enhances mitochondrial complex activity, particularly complexes I-IV, and increases cellular oxygen consumption, indicating improved mitochondrial respiration efficiency. These effects were observed at nanomolar concentrations, suggesting high potency for biological applications2.
The study provides mechanistic insight into how methylene blue might exert its clinical benefits across various conditions. By enhancing mitochondrial function and cellular energetics, methylene blue may address a common pathophysiological mechanism underlying many neurological and age-related disorders, particularly those involving oxidative stress and impaired energy metabolism. These findings help explain methylene blue's diverse therapeutic effects observed in clinical studies2.